Home > Research Groups > Xinyu Zhang

Bioinformatics platform  


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Principal Investigator:Xinyu Zhang, Ph.D., Associate professor   









Educational & Professional Experience
2004-2007, Ph.D., Tsinghua University, China;
2009-2011, Postdoctoral Fellow, Tsinghua University, China;
2011-present, Associate Professor, Institute of Microbiology, Chinese Academy of Sciences.

Research Area
High-throughput data analysis, including NGS/microarray/MS/EST, and so on; especially in GWAS, comparative genomics, functional genomics, meta-analysis and heterogeneous data integration.


Selected Publications
1. Zhang X-Y, Zhang KT, Tian F, Xia Y, Wu YQ, Liu XJ. Integrative analysis and validation of robust gene signature in lung cancer. Biochemical and biophysical research communications, 2007, 358(3):710-715. (SCI)
2. Zhang X-Y, Li TT, Liu XJ. Detecting robust gene signature through integrated analysis of multiple types of high-throughput data in liver cancer. Acta Pharmacol Sin, 2007, 28(12):2005-2010. (SCI)
3. Zhang X-Y, Hu Y, Cui YP, Miao XP, Tian F, Xia YJ, Wu YQ, Liu X. Integrated genome-wide gene expression map and high-resolution analysis of aberrant chromosomal regions in squamous cell lung cancer. FEBS Lett, 2006, 580(11):2774-2778. (SCI)
4. Zhang X-Y*, Shi L, Yan Liu, Tian F, Zhao H-T, Huang M-L, Zhu X-Y. ICPS: an Integrative Cancer Profiler System. Bioinformatics, Epub 2010, Aug 24:2649-2650. (SCI)
5. Zhang X-Y, Sun W-Y, Gao Y-N, Cheng S-J. Construction of High-throughput Analysis System for cDNA library. China Journal of Bioinformatics, 2003, 1(1):6-10.
6. Zhang X-Y, Sun W-Y, Gao Y-N, Cheng S-J. In silico automatically SAGEmap analysis and nucleic acid sequence mapping in Chromosomes. China Journal of Bioinformatics, 2004, 2(1):22-24.
7. Zhang X-Y, Sun W-Y, Gao Y-N, Cheng S-J. To design PCR primers with the software Oligo 6 and Primer Premier 5. China Journal of Bioinformatics, 2004, 2(4):15-18.
8. Zhang X-Y, Wang L, Li GY, Zhu YX. The extraction, isolation and purification of selenium polysaccharide from marine alga. OCEANOLOGIA ET LIMNOLOGIA SINICA 2000, 31(6):643-646.
9. Tian F, Zhang HY, Zhang X-Y, Song C, Xia YJ, Wu YQ, Liu XJ. miRAS: a data processing system for miRNA expression profiling study. BMC Bioinformatics, 2007, 8(1):285. (SCI)
10. Wang HB, Li H, Wang QG, Zhang X-Y, Wang SZ, Wang YX, Wang XP. Profiling of chicken adipose tissue gene expression by genome array. BMC Genomics, 2007, 8(1):193. (SCI)
11. Liu Y, Sun W, Zhang K, Zheng H, Ma Y, Lin D, Zhang X-Y, Feng L, Lei W, Zhang Z, Guo S, Han N, Tong W, Feng X, Gao Y, Cheng S. Identification of genes differentially expressed in human primary lung squamous cell carcinoma. Lung cancer (Amsterdam, Netherlands), 2007, 56(3):307-317. (SCI)
12. Wang X, Zhao H, Xu Q, Jin W, Liu C, Zhang H, Huang Z, Zhang X-Y, Zhang Y, Xin D, Simpson AJ, Old LJ, Na Y, Zhao Y, Chen W. HPtaa database-potential target genes for clinical diagnosis and immunotherapy of human carcinoma. Nucleic acids research, 2006, 34(Database issue):D607-612. (SCI)
13. Zhang X, Miao X, Tan W, Ning B, Liu Z, Hong Y, Song W, Guo Y, Zhang X-Y, Shen Y, Qiang B, Kadlubar FF, Lin D. Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Gastroenterology, 2005, 129(2):565-576. (SCI)
14. Yue CM, Bi MX, Tan W, Deng DJ, Zhang X-Y, Guo LP, Lin DX, Lu SH. Short tandem repeat polymorphism in a novel esophageal cancer-related gene (ECRG2) implicates susceptibility to esophageal cancer in Chinese population. International journal of cancer, 2004, 108(2):232-236. (SCI)
15. Sun W, Zhang K, Zhang X-Y, Lei W, Xiao T, Ma J, Guo S, Shao S, Zhang H, Liu Y, Yuan J, Hu Z, Ma Y, Feng X, Hu S, Zhou J, Cheng S, Gao Y. Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization. Cancer Lett, 2004, 212(1):83-93. (SCI)
16. Cui YP, Wang JB, Zhang X-Y, Bi MX, Guo LP, Lu SH. Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. World J Gastroenterol, 2003, 9(9):1892-1896. (SCI)
17. Cui YP, Wang J, Zhang X-Y, Lang R, Bi M, Guo L, Lu SH. ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. Biochemical and biophysical research communications, 2003, 302(4):904-915. (SCI)