微生物次生代谢产物结构与功能课题组 组长：车永胜 博士 研究员 电话/传真：+86（10）82618785 电子邮件：cheys@im.ac.cn

车永胜研究员简介：

简历：

1985.9-1989.7 南开大学化学系, 高分子专业, 学士学位
1994.1-1995.6 Clarkson University, Organic Chemistry, 硕士学位
1995.8-2000.3 University of Iowa, Organic Chemistry, 博士学位
2000.3-2002.8 OSI Pharmaceuticals, Inc. 高级研究员
2002.8-2005.1 Givaudan 高级研究员
2005.2-今 中科院微生物所, 研究员，入选“百人计划”

学术兼职：

中国科学院微生物研究所学术委员会委员、中国科学院真菌地衣重点实验室学术委员会委员；中国天然药物编委。

目前承担科研项目情况：

源于特定真菌类群的抗真菌活性次生代谢产物的筛选与研究，国家自然科学基金面上项目。
微生物及其代谢产物高通量筛选方法及模型的建立，中国科学院知识创新工程重要方向性项目。
微生物次生代谢产物的结构与功能研究，“百人计划”。
极端微生物的生物多样性及潜在的应用价值评估，国家重点基础研究发展计划(973计划)“极端微生物及其功能利用的基础研究”项目课题。
特殊食药用菌物资源挖掘及产业化技术研究, 863重点项目子课题。
生色化合物库的构建及在细菌检测中的应用，国际合作(Thermo-Fisher)。
食用菌中天然调味剂的研究与开发，国际合作(Givaudan)

研究方向与目标：

    真菌及极端环境微生物因其生存环境的多样性和代谢途径的复杂性因而具有丰富的代谢产物，本实验室以真菌及极端环境微生物为研究对象，以微生物次生代谢产物及其生态功能为研究方向。

    通过对独微生物类群的次生代谢产物进行筛选与化学研究，发现在人类健康及农作物害虫防治方面具有应用潜力的新结构功能次生代谢产物，并通过长期研究力争解释重要生态现象的化学基础。

主要研究内容：

1．微生物次生代谢产物的高通量筛选与化学研究：以重要疾病为靶标，进行微生物次生代谢产物的高通量筛选及化学研究，并研究活性化合物的作用机制，为开发自主知识产权的新药提供候选化合物；
2．微生物化学生物学(Microbial Chemical Biology)：基于生态现象，以生物活性为指导，从微生物(特别是真菌)次生代谢产物中发现抗细菌、真菌及农作物害虫的新结构天然产物；特殊类群真菌生物多样性及其次生代谢产物结构与功能多样性研究，目标是阐明真菌之间及真菌与其生存环境之间的相互作用关系及化学基础；
3．复杂天然有机化合物的结构解析。

研究队伍：

李二伟，博士，助理研究员，天然产物化学。 liew@im.ac.cn.
姜立花，硕士，助理研究员，筛选模型构建及活性测试。jianglh@im.ac.cn.
郭慧娟，硕士，研究实习员，天然产物化学。guohj@im.ac.cn
刘速春，学士，研究实习员，代谢产物制备。liusc@im.ac.cn

博士研究生：邹先伟，刘玲，丁刚，张永刚，李彦，罗辑。

硕博连读生：林杰，李剑，张帆，王寅超，马成。

已毕业或离开人员：

胡合姣，硕士，研究实习员，天然产物化学（2005.4-2006.3）- 美国
郭慧娟，本组硕士毕业，天然产物化学（2004.8-2007.8）- 留本组工作
张楠，学士，生物工程

代表性论文

Yali Chen, Huijuan Guo, Chaoyang Du, Xingzhong Liu, Yongsheng Che*, Xin Ye* (2009), Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducers, Cell Proliferation, (on line) PDF (IF 2.423)

Yonggang Zhang, Shunchun Liu, Hongwei Liu*, Xingzhong Liu & Yongsheng Che*. 2009. Cycloaspeptides F and G, cyclic pentapeptides from a Cordyceps-colonizing isolate of Isaria farinosa. Journal of Natural Products. 72:1364-1367. PDF (IF 2.843)

Ling Liu,Shunchun Liu, Shubin Niu, Liangdong Guo, Xulin Chen & Yongsheng Che*. 2009. Isoprenylated chromone derivatives from the plant endophytic fungus Pestalotiopsis fici. Journal of Natural Products. doi:10.1021/np900308s  (IF 2.843)

Gang Ding, Zhihui Zheng, Shunchun Liu, Hua Zhang, Liangdong Guo & Yongsheng Che*. 2009. Photinides A–F, cytotoxic benzofuranone-derived γ-lactones from the plant endophytic fungus Pestalotiopsis photiniae. Journal of Natural Products. 72:942–945. PDF (IF 2.843)

Yan Li, Dezan Ye, Xulin Chen, Xinhua Lu, Zongze Shao, Hua Zhang & Yongsheng Che*. 2009. Breviane spiroditerpenoids from an extreme-tolerant Penicillium sp. isolated from a deep sea sediment sample. Journal of Natural Products 72:912–916. PDF (IF 2.843)

Ling Liu, Yan Li, Shunchun Liu, Zhihui Zheng, Xulin Chen, Hua Zhang, Liangdong Guo & Yongsheng Che*. 2009. Chloropestolide A, an antitumor metabolite with an unprecedented spiroketal skeleton from Pestalotiopsis fici. Organic Letters 11:2836–2839. PDF (IF 5.128)

Ling Liu, Shunchun Liu, Lihua Jiang, Xulin Chen, Liangdong Guo & Yongsheng Che*. 2008. Chloropupukeananin, the First Chlorinated Pupukeanane Derivative and Its Precursors from Pestalotiopsis fici. Organic Letters. DOI: 10.1021/ol800136t.  PDF (IF 4.802)

Yonggang Zhang, Renrong Tian, Shunchun Liu, Xulin Chen, Xingzhong Liu & Yongsheng Che*. 2008. Alachalasins A-G, New Cytochalasins from the Fungus Stachybotrys charatum. Bioorganic & Medicinal Chemistry. 16:2627-2634. PDF (IF 2.662)

Erwei Li, Lihua Jiang, Liangdong Guo, Hua Zhang & Yongsheng Che*. 2008. Pestalachlorides A-C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta. Bioorganic & Medicinal Chemistry. Accepted. (IF 2.662)

Ling Liu, Shuchun Liu, Xulin Chen, Liangdong Guo & Yongsheng Che*. 2008. Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici. Bioorganic & Medicinal Chemistry. (accepted). (IF 2.662)

Ling Liu,Renrong Tian,Shuchun Liu,Xulin Chen,Liangdong Guo & Yongsheng Che*.2008. Pestaloficiols A–E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici. Bioorganic & Medicinal Chemistry. Accepted (IF 2.662)

Gang Ding,Yan Li,Shaobin Fu,Shuchun Liu,Jiangchun Wei & Yongsheng Che*. 2008. Ambuic Acid and Torreyanic Acid Derivatives from the Endolichenic Fungus Pestalotiopsis sp. Journal of Natural Products. Accepted. (IF 2.551)

Erwei Li, Renrong Tian, Shunchun Liu, Xulin Chen, Liangdong Guo & Yongsheng Che*. 2008. Pestalotheols A-D, Bioactive Metabolites from the Plant Endophytic Fungus Pestalotiopsis theae. Journal of Natural Products. DOI: 10.1021/np700744t.  PDF (IF 2.551)

Gang Ding, Shunchun Liu, Liangdong Guo,Yuguang Zhou & Yongsheng Che*. 2008. Antifungal Metabolites from the Plant Endophytic Fungus Pestalotiopsis Foedan. Journal of Natural Products. DOI: 10.1021/ np 070590f. PDF (IF 2.551)

Yan Li, Bingda Sun, Shuchun Liu, Lihua Jiang, Xingzhong Liu, Hua Zhang & Yongsheng Che*. 2008. Bioactive Asterric Acid Derivatives from the Antarctic Ascomycete Fungus Geomyces sp. Journal of Natural Products. Accepted. (IF 2.551)

Gang Ding, Lihua Jiang, Liangdong Guo, Xulin Chen, Hua Zhang & Yongsheng Che*. 2008. Pestalazines and Pestalamides, Bioactive Metabolites from the Plant Pathogenic Fungus Pestalotiopsis theae. Journal of Natural Products. Accepted. (IF 2.551)

Guo H, Hu H, Liu S, Liu X, Zhou Y, Che Y*. 2007. Bioactive p-Terphenyl Derivatives from a Cordyceps-Colonizing Isolate of Gliocladium sp. J. Nat. Prod. 70:1519-1521.

Zhang Y, Liu S. Che Y*, Liu X. 2007. Epicoccins A-D,??? Epipolythiodioxopiperazines from a Cordyceps-Colonizing Isolate of Epicoccum nigrum. J. Nat. Prod. 70:1522-1525.

Gao L, Sun MH, Liu XZ, Che Y. 2007. Effects of carbon concentration and??? carbon to nitrogen ratio on the growth and sporulation of several biocontrol fungi. Mycol. Res. 111:87-92.

Hu H, Guo H, Li E, Liu X, Zhou Y, Che Y*. 2006. Decaspirones F-I, New Bioactive Secondary Metabolites from the Saprophytic Fungus Helicoma viridis. J. Nat. Prod. 69:1672-1675.

Boros C, Smith CJ, Vasina Y, Che Y, Dix AB, Darveaux B, Pearce C. 2006. Isolation and Identification of the Icosalides-cyclic Peptolides with Selective Antibiotic and Cytotoxic Activities. J. Antibiot. 59:486-494.

Feng J#, Che Y#, Milse J, Yin YJ, Ruckert C, Shen XH, Qi SW, Kalinowski J, Liu SJ. 2006. ?The Gene ncgl2918 Encodes a Novel Maleylpyruvate Isomerase That Needs Mycothiol as Cofactor and Links Mycothiol Biosynthesis and Gentisate Assimilation in Corynebacterium Glutamicum. J. Biol. Chem. 281:10778-10785.

Yang XG, Jordan J, Vernice GG, Che Y. 2005. Deuterium Distribution in Benzaldehyde Molecules by SNIF-NMR Analysis, in Natural Flavor and Fragrances, Chemistry, Analysis, and Production. Frey, C, Rouseff, RL, Eds；Oxford University Press: Oxford, p.79-90.

Che Y, Gloer JB, Scott JA, Malloch D. 2005. Communiols E-H: New Bioactive Secondary Metabolites from the Coprophilous Fungus Podospora communis. J. Nat. Prod. 68:435-438.

Che Y, Gloer, JB, Wicklow DT. 2004. Curvicollides A-C: New Polyketide-Derived Lactones from a Sclerotium-Colonizing Isolate of Podospora curvicolla (NRRL 25778). Org. Lett. 6:1249-1252.

Che Y, Gloer JB, Scott JA, Malloch D. 2004. Communiols A-D: New Mono- and Bis-Tetrahydrofuran Derivatives from the Coprophilous Fungus Podospora communis. Tetrahedron Lett. 45:6891-6894

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